Guide
How long do GLP-1 medications stay in your system?
A medication's half-life is how long it takes for the amount in your body to fall by half. Weekly medications have long half-lives, so they build up over a few weeks and take several weeks to clear after the last dose. Daily medications clear faster.
| Medication | Ingredient | Taken | Half-life (FDA label) |
|---|---|---|---|
| Ozempic, Wegovy | semaglutide injection | Weekly | About 1 week |
| Ozempic Pill, Wegovy Pill, Rybelsus | semaglutide tablet | Daily | About 1 week |
| Mounjaro | tirzepatide | Weekly | About 5 days |
| Zepbound | tirzepatide | Weekly | About 5 to 6 days |
| Trulicity | dulaglutide | Weekly | About 5 days |
| Foundayo | orforglipron | Daily | About 29 to 49 hours |
| Saxenda, Victoza | liraglutide | Daily | About 13 hours |
Values from each product's FDA prescribing information, section 12.3 (Pharmacokinetics), reviewed October 29, 2026. Individual results vary.
What this means day to day
Half-life helps explain why a weekly dose keeps working all week and why effects can linger after stopping. It does not tell you when to take, skip or change a dose. If you miss a dose or want to stop, follow your product label and ask your prescriber or pharmacist.
Pavuno is a tracking tool. It does not prescribe, recommend or adjust doses, and it is not medical advice. Always follow your licensed clinician and the product label. Medication names are trademarks of their owners; Pavuno is not affiliated with or endorsed by them.
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